| Customization: | Available |
|---|---|
| CAS No.: | 53123-88-9 |
| Formula: | Yes |
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Rapamycin is synthesized from seven units of acetate and seven units of propionate via the polyketone pathway, with the required O-methyl derived from methionine. In fact, shikimic acid is a reduced derivative of nitrogen source, and the integrity of cyclohexyl is preserved during the formation derivatives from shikimic acid. Lysine was first deaminated to form piperidine carboxylate, and then piperidine carboxylate was connected with polyketoacetyl and amide bonds to form the initial structure of rapamycin.
| Item | Specifications | Results |
| Description | White or almost white powder | Complies |
Identification |
The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard | Complies |
| The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm,277nm, 288nm that of similar preparation of in-house reference standard. | Complies | |
| The retention times of the peaks for the Trans- and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the Assay | Complies | |
| Loss on drying | ≤0.5% | 0.16% |
| Heavy metal | ≤0.002% | Complies |
| Total impurity | ≤2.0% | 0.76% |
| Single impurity | ≤1.0% | 0.67% |
| Cis-stereoisomer of Sirolimus | ≤5.0% | 2.4% |
| Assay | ≥99.0% | 99.2% |
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